Ready for a Closeup:

Differentiating Inadequate Response and Emotional Blunting During Treatment for Major Depressive Disorder

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Watch this “cinemeducation” video from start to finish for a complete, sequential learning experience OR skip around by clicking on the individual cases listed above to watch each of them in any order that suits your educational needs.

To view for CME credit click here


Major depressive disorder is not just about feeling “down.” It’s a life-threatening condition that is a leading cause of suicide. Fortunately, there are a variety of effective therapies; however, many patients may have an inadequate response to treatment and others may experience anhedonia or reduced emotional responsiveness (ie, emotional blunting) associated with both selective serotonin reuptake inhibitors/serotonin-norepinephrine reuptake inhibitors (SSRIs/SNRIs).

Do you have questions about the symptoms of emotional blunting or differentiating emotional blunting from inadequate treatment response? What about assessing the effectiveness of different therapies? This innovative “cinemeducation” format is where patient and clinician dialogues come to life to model best practices. Find out how to use measurement-based care for tracking symptoms of depression; assess and manage treatment-related emotional blunting; and involve patients in shared decision making.

Enhance your clinical practices and help your patients find the light again.

Hear More From Our Faculty

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Becoming more attuned to emotional blunting

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Considering a diagnosis of emotional blunting

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Determining a patient's most problematic symptoms

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How patients may respond to emotional blunting as a side effect of treatment

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Managing comorbidities in patients with MDD

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Supporting patients with MDD


Collaborating with Patients with Major Depressive Disorder to Achieve Full Functional Recovery

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Join Anita Clayton, MD from the University of Virginia School of Medicine, Roger McIntyre, MD, FRCPC, from the University of Toronto, Michael Thase, MD, from the Perelman School of Medicine at the University of Pennsylvania! Discussion will focus on the latest evidence for treatment for MDD, including growing awareness around the recognition and impact of emotional blunting. Faculty will also discuss the importance of shared decision making with patients, while adjusting medication dose or switching treatments.

Special thanks to Anita Clayton, MD, Roger McIntyre, MD, FRCPC, Michael Thase, MD, and The Mighty whose guidance and expertise were used in the development of this educational resource.

Supported by an educational grant from Takeda Pharmaceuticals U.S.A., Inc.

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